Title: Locally Applied FK506 Improves Functional Recovery in Rats after Sciatic Nerve Transection

Author(s) - Eduardo Goldani*1, Marco Antônio Smiderle Gelain2, Thomaz Monteiro Cardoso2,  Alice Cardoso Pellizzari3, Mariana Dias Curra3, Thaís Mariel Andara Beuren3, Juliana Oliveira Rangel4, Jefferson Braga Silva5

 DOI: - 10.23958/ijirms/vol02-i06/03


Peripheral nerve injury (PNI) is a serious health concern for society and often causes long lasting disability. Nerve tubulization is recommended when there is too much tension for end-to-end coaptation and the gap between stumps is shorter than 3 cm. The immunosuppressive drug FK506 (Tacrolimus) has demonstrated neuroprotective and neurotrophic actions in experimental models by increasing neurite elongation and accelerating the rate of nerve regeneration in vitro and in vivo. The aim of this study was to evaluate functional recovery through walking track analysis after nerve transection with loss of substance. FK506 was used as a neurotrophic factor to stimulate neuronal growth through the tubulization technique along with a controlled drug delivery system, the alzet osmotic minipumps. Rats (n=36) were randomly assigned to three groups. Group I served as untreated controls. Groups II and III received 0.1 mg/kg/d of FK506 systemically and locally, respectively. After 90 days postoperative results showed the Group III achieved the best functional recovery (highest Sciatic Functional Index – SFI) in comparison with Groups I and II.

Keywords: peripheral nerve injury, tubulization, FK506, osmotic pumps.

How to Cite this Article?

"Eduardo Goldani, Marco Antônio Smiderle Gelain, Thomaz Monteiro Cardoso, Alice Cardoso Pellizzari, Mariana Dias Curra, Thaís Mariel Andara Beuren, Juliana Oliveira Rangel, Jefferson Braga Silva" ‘Locally Applied FK506 Improves Functional Recovery in Rats after Sciatic Nerve TransectionInternational Journal of Innovative Research in Medical Science(IJIRMS), http://ijirms.in/index.php, Volume 2 Issue 6, June 2017, p. No. 789-796