Title: The Prognostic Value of β-catenin Expression in Endometrial Cancer

Author(s) - Yong Il Ji

 DOI: - 10.23958/ijirms/vol02-i11/01


Objective: To investigate the prognostic value of β-catenin expression in endometrial cancer.

Methods: Immunohistochemistry was used to evaluate samples from 27 early stage and 39 advanced stage endometrial cancers. Smears were examined for the expression of β-catenin protein in the cell membrane, cytoplasm, and nucleus. The staining patterns were then evaluated for their correlation with several prognostic factors, including 5-year survival.

Results: Decreased cell membrane β-catenin expression was significantly associated with advanced stage (stage III–IV), high grade (grade 3), deep (>50%) myoinvasion, and positive lymph node status (P < 0.05). Negative membrane staining for β-catenin was associated with a lower 5-year survival rate, compared to that for positive staining (51.7% vs. 86.6%, respectively; P < 0.05).

Conclusions: Loss of membrane β-catenin expression is a strong and independent predictor of unfavorable outcomes in patients with endometrial carcinoma.

Keywords: endometrial cancer, beta-catenin, immunohistochemistry.

How to Cite this Article?

"Yong Il Ji" ‘The Prognostic Value of β-catenin Expression in Endometrial Cancer" International Journal of Innovative Research in Medical Science(IJIRMS), http://ijirms.in/index.php, Volume 2 Issue 11, November 2017, p. No. 1448-1457