Title: Clinical Parameters of Metabolic Syndrome in Schizophrenia and Bipolar Disorder: A Cross Sectional Study

Author(s) - V.S. Pal1, Dheerendra Kumar Mishra*2, Pali Rastogi1

 DOI: - 10.23958/ijirms/vol02-i11/04


Abstract:

Introduction: Schizophrenia and bipolar disorder are serious mental illness and need long-term antipsychotics for management. Olanzapine is most commonly used atypical antipsychotics with high risk for metabolic syndrome. Monitoring of metabolic parameters are advised but many times unavailability of biochemical parameters of metabolic syndrome clinical parameters are only can be measured, so that prevalence of impaired clinical parameters of metabolic syndrome is not known in serious mental illness.

Aim: To study the clinical parameters among the schizophrenics and bipolar disorders patients taking Olanzapine.

Methods: Cross-sectional assessments were done on 118 subjects (>18 years), Subjects taking Olanzapine at least for 6 months for schizophrenia and bipolar disorder was recruited from the outpatient department of a tertiary care hospitals. Data was collected on socio-demographic characteristics, Clinical parameters of metabolic syndrome as per NCEP ATP III criteria were evaluated

Results: Study sample schizophrenics was 67.80 % and mean duration of illness in schizophrenics vs. Bipolar disorder was 10.18 ± 6.29 vs. 9.47 ± 6.93 years respectively. Mean dose of Olanzapine in schizophrenics vs. Bipolar disorder 13.75 ± 5.36 vs. 12.63 ± 4.75 mg per day. 50.84 % subjects had central obesity, 44.06 % had impaired SBP, and 40.67 % impaired DBP. No statically significant difference of clinical parameters of metabolic syndrome between schizophrenia and bipolar disorder.

Conclusion: Impairment in clinical parameters of metabolic syndrome was significantly higher in schizophrenia and bipolar disorder patients taking Olanzapine and there was no significant difference among schizophrenics and bipolar disorder patients.

Keywords: Clinical parameters, Metabolic syndrome, Olanzapine, Schizophrenia, Bipolar disorder


How to Cite this Article?

"V.S. Pal, Dheerendra Kumar Mishra*, Pali Rastogi" ‘Clinical Parameters of Metabolic Syndrome in Schizophrenia and Bipolar Disorder: A Cross Sectional Study" International Journal of Innovative Research in Medical Science(IJIRMS), http://ijirms.in/index.php, Volume 2 Issue 11, November 2017, p. No. 1476-1481

Impact Factor

SJIF Impcat Factor - 4.102

Indexcopernicus ICV - 64.48

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