Title: Relation of Vitamins in Diabetes Melliatus
Author(s) - Dr. Vaibhav D. Lotake, Dr. Supriya Barsode
DOI: - 10.23958/ijirms/vol03-i04/03
Abstract: - Introduction
Diabetes is a chronic metabolic disorder which is linked to energy metabolism, particularly carbohydrate and fat. Obesity and physical inactivity are shown to be the major risk factors for type 2 diabetes (T2DM). Oxidative stress may also contribute to increase in blood glucose levels, thus contribute to the pathogenesis of T2DM by increasing insulin resistance or impairing insulin secretion. The consequences and complications of diabetes are due to imbalance between free radical formation and their control by natural antioxidants. Thus nutrients having antioxidant function are important in disease development and control also non oxidant vitamins have also shown relationship with diabetes. Long-term treatment of diabetic patients with metformin may cause a higher risk of developing vitamin B-12 deficiency. Vitamin A plays important role as antioxidant, thus helping to maintain the organism’s homeostasis when subjected to various forms of stress. Vitamin B6 consists of a group of three compounds: Pyridoxal, pyridoxine and pyridoxamine, and their corresponding phosphorylase forms and the active form of this vitamin is pyridoxal-5’-phospate (PLP). In new diabetic patients lower PLP concentrations were found as compared to non-diabetic persons. Niacin or B3, Nicotinic acid is a component of NAD and NADH, which are essential for ATP production and energy efficiency at the cellular level and has been found to increase HDL-cholesterol, decreases TG and LDL cholesterol. As T2DM is an oxidative stress disease; vitamin B12 and folic acid deficiencies in diabetic subjects have been found associated to oxidative stress so it is conceivable that vitamin B12 deficiency should be considered a risk factor for diabetic complications. Plasma vitamin C concentrations have been inversely correlated to glycosylated hemoglobin and fasting and postprandial blood, Vitamin C has also been shown to reduce anxiety levels. and supplementation for 3 months of vitamins C and E decreases hypertension, blood glucose while increasing superoxide dismutase and glutathione levels. Vitamin D may play an important role in modifying the risk of diabetes. The role of vitamin D in the function of pancreatic cells can be mediated by the union of 1,25-dihydroxyvitamin D to its receptors in the beta cell.
How to Cite this Article?
"Dr. Vaibhav D. Lotake, Dr. Supriya Barsode" ‘‘Relation of Vitamins in Diabetes Melliatus" International Journal of Innovative Research in Medical Science(IJIRMS), http://ijirms.in/index.php, Volume 03 Issue 04, April 2018, p. No. 1925-1928