Abstract

Background: Vitamin B₁₂ is an essential element for proteins, phospholipids metabolism and neurotransmitters synthesis. It also plays a key role in DNA biosynthesis and cellular energy production. However, vitamin B₁₂ deficiency leads to neurologic and psychiatric disturbances including depression, dementia, and a demyelinating myelopathy. Moreover, it’s also associated with other diseases such as pernicious anemia and other hematologic manifestation.

Methods: After approval from Hebron Charitable Medical Center (HCMC), a retrospective study was carried out among patients at Charitable Medical Center (HCMC) in Hebron, Palestine. It was carried out over a period of one year and half starting from January 2013 till June 2014.

Aim: This study was conducted to determine the prevalence of vitamin B₁₂ among the patients of HCMC.

Results: In general, a total of 305 patients screened for serum vitamin B₁₂ levels were enrolled. There were 90 (29.5%) men and 215 (70.5%) women, there were 285 (93.4%) <60 years old and 20 (6.6%) >60 years old .There were 50 patients (16.4%) had vitamin B₁₂ deficiency. Mean ± SEM levels of B₁₂ in 305 subjects were observed to be 389.73.1±12.93 (range: 60 - 1432 pg/ml). Men had mean value of 423.11±30.17 (range: 60 - 1432 pg/ml) and women had 375.75±13.24 (range: 76 - 1292 pg/ml).

Conclusion: This study had highlighted a number of patients that reveals Vitamin B₁₂ deficiency according to gender and age. We recommend the necessary implementation of Vitamin B₁₂ supplements for all men and women with any age.