Analgesic Effect of Zolmitriptan Nanoparticles in Experimental Animal Models

Article Date Accepted: !dateAccepted; | Article Date Published : 6 August 2018 | Page No.: 2103 to 2107


Background: Zolmitriptan is used to treat migraine and certain other headaches. This study has been done to prepare specific Zolmitriptan Nano-nasal spray (Z-NPS) by ion gelation technique to evaluate the efficacy of analgesic activity of test drug as a nano nasal spray of Zolmitriptan (Z-NPS) and conventional preparation as a standard drug (Zolmist) against Nitro-glycerine induced migraine. The study was performed on mice by using hot plate method. Methods: In this study male Swiss albino mice weighing between 25-30 grams were taken and divided into 4 groups with 6 mice in each group. Zolmitriptan loaded chitosan nanoparticles (Z-NPS) was administered nasally (using specific inhalation mask) at a dose of 5 mg/kg and was compared with the control group which received water for injection and the standard drug Zolmitriptan (Zolmist) at a same dose in mice induced migraine using hot plate method. Reaction times were measured at 10, 20, 30 and 60 minutes after drug administration. Results: The test drug (Z-NPS) at a dose of 5 mg/kg after 10 minutes of drug administration showed an increase in the reaction time compared to the standard drug (Zolmist) at same dose of drug administration. However, Z-NPS showed significant increase in the reaction time after 10 minutes as compared to Zolmist. Conclusion: Zolmitriptan has significant analgesic properties in central-analgesic model i.e. Hot-plate method. The test drug could be used for anti-migraine activity.

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Zadeh Khezri, M. F. A. N., Nargund, D. S., Lakshmi, D. C. S. R., Nargund, D. L. V. G., Alisani, D. R., & Mohammadi, A. (2018). Analgesic Effect of Zolmitriptan Nanoparticles in Experimental Animal Models. International Journal of Innovative Research in Medical Science, 3(07), 2103 to 2107.

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Issue: Vol 3 No 07 (2018)
Page No.: 2103 to 2107
Section: Articles

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