@article{Martin Thierry_Minoué Kuum_Temdie Guemmogne_Tchadji_Lissom_Dimo_2018, title={Anti-inflammatory Effects of the Stem Barks from Albizia Ferruginea (Mimosaceae) on Chronic Inflammation Induced in Rats}, volume={3}, url={https://ijirms.in/index.php/ijirms/article/view/423}, DOI={10.23958/ijirms/vol03-i09/423}, abstractNote={<p><em>Albizia ferruginea </em>is used in popular medicine for the treatment of inflammatory illnesses. The chronic anti-inflammatory effects of aqueous extract of <em>A. ferruginea </em>was assessed on the cotton pellet-induced granuloma, formalin and complete Freund’s adjuvant-induced inflammation. The aqueous extract of <em>A. ferruginea </em>was administered orally at the doses of 100 and 200 mg/kg. It’s showed that <em>A. ferruginea </em>extract (100 or 200 mg/kg) significantly (<em>p<0.001</em>) inhibited the granuloma formation induced by cotton pellets by 41.70 % and 46.10 %, respectively. <em>A. ferruginea </em>extract, at the dose of 200 mg/kg inhibited (<em>p<0.01</em>) the paw œdema induced by formalin (25.79 %) and Complete Freund’s adjuvant (CFA) in rats(47.40 %).<em>A. ferruginea </em> extract(100 or 200 mg/kg) normalized the level of white blood cells, red blood cells, hemoglobin, and platelets of rats treated with CFA. Glutathione and superoxide dismutase levels were significantly increase (92.59% and 60.51%, respectively), catalase activity was significantly increased (42.03%) in the tissue of CFA rats treated with <em>A. ferruginea </em>(200 mg/kg). Malondialdehyde level was reduced by 72.88% (p<0.01) in spleen of rats treated with <em>A. ferruginea </em>aqueous extract. The nitrite level was significantly decreased by 50.51% in liver of CFA rats treated with <em>A. ferruginea </em>(200 mg/kg). These results show that aqueous extract of <em>A. ferruginea </em>may possess anti-inflammatory effects on chronic inflammation, which could be partially attributed to its antioxidant properties.</p>}, number={09}, journal={International Journal of Innovative Research in Medical Science}, author={Martin Thierry, Bella Ndzana and Minoué Kuum, Marc Germain and Temdie Guemmogne, Roméo Joël and Tchadji, Jules Colince and Lissom, Abel and Dimo, Théophile}, year={2018}, month={Sep.}, pages={2183 to 2195} }