High-sensitive Biomarkers of Blood Antiradical Activity in Mice Exposed to γ-irradiation

S. Kalmakhelidze; T. Sanikidze; D. Topuria; I. Chkhikvishvili; E. Shekiladze; N. Ivanishvilli; M. Gogebashvili; E. Lomadze; G. Ormotsadze

doi:10.23958/ijirms/vol06-i03/1088

Open Access Publication ISSN: 2455-8737 |

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Original Article | Open Access

Vol. 6 No. 03 (2021) | Page No.: 197 - 200 | https://doi.org/10.23958/ijirms/vol06-i03/1088

High-sensitive Biomarkers of Blood Antiradical Activity in Mice Exposed to γ-irradiation

S. Kalmakhelidze⁺⁻
T. Sanikidze⁺⁻
D. Topuria⁺⁻
I. Chkhikvishvili⁺⁻
E. Shekiladze⁺⁻
N. Ivanishvilli⁺⁻
M. Gogebashvili⁺⁻
E. Lomadze⁺⁻
G. Ormotsadze⁺⁻

Department of Medical Physics and Biophysics, Tbilisi State Medical University, Tbilisi/ 0177, Georgia. Department of Neurotoxicology, Beritashvili Center of Experimental Biomedicine, Tbilisi/0160, Georgia

Department of Medical Physics and Biophysics, Tbilisi State Medical University, Tbilisi/ 0177, Georgia. Department of Radiobiology, Beritashvili Center of Experimental Biomedicine, Tbilisi/0160, Georgia

Department of Normal Anatomy Tbilisi State Medical University, Tbilisi/0177, Georgia

Department of Medical Physics and Biophysics, Tbilisi State Medical University, Tbilisi/ 0177, Georgia. V. Bakhutashvili Institute of Medical Biotechnology of Tbilisi State Medical University, Tbilisi/0159, Georgia

Department of Medical Physics and Biophysics, Tbilisi State Medical University, Tbilisi/ 0177, Georgia. Department of Biophysics, Javakhishvili Tbilisi State University, Tbilisi/0167, Georgia

Department of Radiobiology, Beritashvili Center of Experimental Biomedicine, Tbilisi/0160, Georgia

Department of Medical Physics and Biophysics, Tbilisi State Medical University, Tbilisi/ 0177, Georgia; Department of Radiobiology, Beritashvili Center of Experimental Biomedicine, Tbilisi/0160, Georgia; Department of Biophysics, Javakhishvili Tbilisi State University, Tbilisi/0167, Georgia

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Published: 2021-03-16

Abstract

Diagnostic markers are important indicators for the assessment of the possible consequences of radiation exposure, which could lead to acute and chronic radiation toxicity. The goal of the study is to determine high-sensitive markers of blood redox status in relation to the dose of radiation.

The mice were exposed to γ-irradiation (Cs137) at a total dose of 3, 5, and 7Gy. After 1, 2, 7, and 14 days of the irradiation, the blood samples were drawn under ether anesthesia from the inferior vena cava and the activity of antioxidant system (enzymatic -superoxide dismutase (SOD), catalase) and non-enzymatic total antioxidant activity (TAA) of blood serum was determined.

The results of our investigation support the fact that the non-enzymatic antioxidant TAA plays an important role in the prevention of radiation damage during ionizing radiation exposure, which makes it possible to consider TAA as a promising candidate as the biomarker of radiation dose.

Keywords: γ-radiation, antiradical system, biodosimetry markers, Georgia

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How to Cite

Kalmakhelidze, S., Sanikidze, T., Topuria, D., Chkhikvishvili, I., Shekiladze, E., Ivanishvilli, N., … Ormotsadze, G. (2021). High-sensitive Biomarkers of Blood Antiradical Activity in Mice Exposed to γ-irradiation. International Journal of Innovative Research in Medical Science, 6(03), 197–200. https://doi.org/10.23958/ijirms/vol06-i03/1088

Copyrights & License

Copyright © 2021 S. Kalmakhelidze T. Sanikidze D. Topuria I. Chkhikvishvili E. Shekiladze N. Ivanishvilli M. Gogebashvili E. Lomadze G. Ormotsadze this is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This work is licensed under a Creative Commons Attribution 4.0 International License.