Abstract

Purpose: - To analyze the level of serum Glutathione-S-Transferase (GST) and Carcinoembryonic antigen (CEA) before and after different Cycles Of chemotherapy in GI carcinoma patients.

Methods: - For the study comprising total 58 cases suffering from GI carcinoma stage I, stage II stage III and Stage IV (before and after different cycle of chemotherapy) were selected. All patients were clinically and histologically diagnosed. A total of 42 age and sex matched healthy subjects taken as control. The circulating levels of GST and CEA activity were assayed in the in the serum of control group and in patients with GI carcinoma.

Results: - Serum level of GST and CEA were highly significant in GI carcinoma patients as compared to control group (p<0.001). After first cycle of chemotherapy (stage II) the activity of GST and CEA were significantly higher than before chemotherapy (stage I). In stage III (after second cycle of chemotherapy) activity was significantly decreased than that of stage II and the activity of GST and CEA was significantly decreased in stage IV (after third cycle of chemotherapy) than stage III (after second cycle of chemotherapy).

Conclusion:-  On the basis of data from our study, it can be stated that serum GST measurement in plasma may be useful tumor marker in gastrointestinal carcinoma, its activity might helpful to predict the response of chemotherapy in advance stage of cancer.

CEA is a tumor marker that is measured using a blood test.CEA tumor marker is one of the general type tumor markers. A multiply increased CEA levels in the blood indicate to the presence of a malignant disease in the body, but not to the organ in which the malignant change has occurred. High levels of CEA may indicate that cancer has spread; however, other medical conditions and some treatments, including certain types of chemotherapy, may raise CEA levels. CEA tests are one way doctors can find out whether the cancer has spread or returned. Cancer that has spread or returned can be treated successfully for many patients. CEA measurement is mainly used to identify recurrences after surgical resection and for staging.