Original ArticleOpen Access

Safety of Nebulization with a Super-Oxidized Solution in Healthcare Personnel Exposed to COVID-19

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DOI: 10.23958/ijirms/vol11-i01/2157· Pages: 22 - 30· Vol. 11, No. 01, (2026)· Published: January 10, 2026
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Abstract

This study presents a case series conducted at a private hospital in Mexico City, where healthcare personnel were exposed to SARS-CoV-2 without adequate protective measures. As a voluntary prophylactic measure, and given the high mortality from COVID-19 at that time, a protocol was implemented consisting of nebulization with a super-oxidized solution (Microdacyn) for 15 minutes, three times daily for 7 days. The objective was to evaluate the safety of this preventive treatment. Specific measurements were obtained in each participant to demonstrate the safety of the procedure. Of eleven initial subjects, eight completed the protocol; one was excluded due to pre-existing cardiac arrhythmia and two were withdrawn for other reasons (one subject had a positive SARS-CoV-2 PCR test, with adequate oxygen saturation and no complications, and another withdrew consent). The mean age of participants was 33.2 years, with three women and five men. The protocol was initiated on the fourth day after exposure. At baseline and at the end of the protocol, SARS-CoV-2 PCR testing, IgG and IgM antibodies, chest radiographs, general blood tests, and spirometry were performed. Positive IgG was found in two subjects who reported symptoms consistent with COVID-19 months earlier. No serious or clinically significant adverse events were reported during treatment; no changes were observed in vital parameters (heart rate, respiratory rate, oxygen saturation), and there were no hospital admissions or deaths. At the end of the protocol, all patients were negative for SARS-CoV-2 by PCR, spirometry did not differ from baseline, and the remaining laboratory and imaging studies showed no significant changes. These results suggest that nebulization with a super-oxidized solution is safe as a prophylactic treatment in individuals at high risk of exposure to SARS-CoV-2, which could serve as a precedent for the management of this and other types of respiratory infections.

Keywords

SARS-CoV-2ultrasonic nebulizationsuper-oxidized solutionprophylaxishealthcare personnelspi

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Author details
Dr. Roberto Carlos Rebollar González
Hospital Ángeles Lindavista. Col. Magdalena de las Salinas - 07760, City (CDMX), Mexico.
✉ Corresponding Author
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Dr. Edgar Torres López
Hospital Ángeles Lindavista. Col. Magdalena de las Salinas - 07760, City (CDMX), Mexico.
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Dr. Fernando Amador Solórzano Trelles
Hospital Ángeles Lindavista. Col. Magdalena de las Salinas - 07760, City (CDMX), Mexico.
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Dr. César Augusto Aguilar Medina
Hospital Ángeles Lindavista. Col. Magdalena de las Salinas - 07760, City (CDMX), Mexico.
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