Abstract

The aim of the study is the assessment of accuracy for the diagnostic evaluation of Wilms tumor in the pediatric population in the era of contrast-enhanced CT scan using histopathology as a gold standard. Plain and contrast-enhanced abdominal Computed Tomography including pelvis and chest was performed in suspected patients with multiple axial sections with sagittal and coronal reconstructions. Patients were being followed, data was collected and recorded on proforma after histopathology. The patient's mean age for this study in years was 3.5 ± 1.2. Gender distribution showed 170 patients (54.6%) were male while the remaining 141 patients (45.33%) were female. Contrast-enhanced computed tomography showed sensitivity (90.36%), specificity (51.72%), diagnostic accuracy (72.34%), positive predictive value (68.18%), and negative predictive value (82.42%) confirmed on Histopathology as the gold standard. It is concluded from the results of this study that contrast-enhanced computed tomography proved high diagnostic accuracy positive predictive in the detection of Wilms’ tumor by taking histopathology as the gold standard.

Keywords: Wilms tumor, accuracy, histopathology, computed tomography, children

Downloads

Download data is not yet available.

References

  1. Diniz G. Histopathological and molecular characteristics of wilms tumor.
  2. McHugh K. Renal and adrenal tumours in children. Cancer imaging. 2007;7(1):41. PMID: 17339140. doi: 10.1102/1470-7330.2007.0007
  3. Davidoff AM. Wilms tumor. Current opinion in pediatrics. 2009 Jun;21(3):357. PMID: 1941766. doi: 10.1097/MOP.0b013e32832b323a
  4. Breslow N, Olshan A, Beckwith JB, Green DM. Epidemiology of Wilms tumor. Medical and pediatric oncology. 1993;21(3):172-81. Doi:10.1002/mpo.2950210305
  5. Poole JE. Wilms’ tumour (nephroblastoma). Continuing Medical Education. 2010;28(7):324-6.
  6. Memon F, Rathi SL, Memon MH. Pattern of solid paediatric malignant neoplasm at LUMHS, Jamshoro, Pakistan. Journal of Ayub Medical College Abbottabad. 2007;19(4):55-7. PMID: 25295119. DOI: 10.3892/ol.2014.2501
  7. Wang J, Li M, Tang D, Gu W, Mao J, Shu Q. Current treatment for Wilms tumor: COG and SIOP standards. World Journal of Pediatric Surgery. 2019 Sep 1;2(3):e000038. doi: 10.1136/wjps-2019-000038
  8. Bhutani N, Kajal P, Sharma U. Many faces of Wilms Tumor: Recent advances and future directions. Annals of Medicine and Surgery. 2021 Mar 7:102202. PMID: 33747498. DOI: 10.1016/j.amsu.2021.102202
  9. Maciaszek JL, Oak N, Nichols KE. Recent advances in Wilms’ tumor predisposition. Human molecular genetics. 2020 Oct 1;29(R2):R138-49. PMID: 32412586. DOI: 10.1093/hmg/ddaa091
  10. Lugtenberg RT, Cransberg K, Loos WJ, Wagner A, Alders M, van den Heuvel-Eibrink MM. Topotecan distribution in an anephric infant with therapy resistant bilateral Wilms tumor with a novel germline WT1 gene mutation. Cancer chemotherapy and pharmacology. 2008 Nov 1;62(6):1039-44. DOI 10.1007/s00280-008-0694-x
  11. Servaes SE, Hoffer FA, Smith EA, Khanna G. Imaging of Wilms tumor: an update. Pediatric radiology. 2019 Oct;49(11):1441-52. Doi:10.1007/s00247-019-04423-3
  12. Just da Costa e Silva E, Alves Pontes da Silva G. Eliminating unenhanced CT when evaluating abdominal neoplasms in children. American Journal of Roentgenology. 2007 Nov;189(5):1211-4.doi.10.2214/AJR.07.2154
  13. Friedman AD. Wilms tumor. Pediatr Rev. 2013 Jul 1;34(7):328-30. PMID: 23818087. DOI: 10.1542/pir.34-7-328
  14. Gupta AK, Chowdhury V, Khandelwal N. Diagnostic radiology paediatric imaging. JP Medical Ltd; 2011.
  15. Miniati D, Gay AN, Parks KV, Naik-Mathuria BJ, Hicks J, Nuchtern JG, Cass DL, Olutoye OO. Imaging accuracy and incidence of Wilms' and non-Wilms' renal tumors in children. Journal of pediatric surgery. 2008 Jul 1;43(7):1301-7. doi.org/10.1016/j.jpedsurg.2008.02.077
  16. Rasool M, Pansota MS, Mumtaz F, Saleem MS, Tabassum SA. Positive predictive value (PPV) of computed tomography in diagnosing wilms’ tumor using histopathology as gold standard. The Professional Medical Journal. 2019 Oct 10;26(10):1755-9. Doi:10.29309/TPMJ/2019.26.10.4136
  17. Gow KW, Roberts IF, Jamieson DH, Bray H, Magee JF, Murphy JJ. Local staging of Wilms' tumor-computerized tomography correlation with histological findings. Journal of pediatric surgery. 2000 May 1;35(5):677-9.
  18. Silva EJ, Silva GA. Local behavior and lymph node metastases of Wilms' tumor: accuracy of computed tomography. Radiologia Brasileira. 2014 Jan;47:9-13. PMID: 10813321. DOI: 10.1053/jpsu.2000.5941
  19. Davidoff AM. Wilms tumor. Advances in Pediatrics. 2012 Jan 1;59(1):247-67. PMID: 22789581. DOI: 10.1016/j.yapd.2012.04.001
  20. Lopes RI, Lorenzo A. Recent advances in the management of Wilms' tumor. F1000Research. 2017;6. PMID: 28620463. doi: 10.12688/f1000research.10760.1
  21. Van Den Heuvel-eibrink MM, Hol JA, Pritchard-Jones K, Van Tinteren H, Furtwängler R, Verschuur AC, Vujanic GM, Leuschner I, Brok J, Rübe C, Smets AM. Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol. Nature Reviews Urology. 2017 Dec;14(12):743-52. PMID: 29089605. doi.org/10.1038/nrurol.2017.163
  22. Leslie SW, Sajjad H, Murphy PB. Wilms tumor (nephroblastoma). StatPearls [Internet]. 2020 Jul 1.
How to Cite
Amirali, A., Darira, J. ., Pathan, H., Murtaza, S., & Irshad, M. . (2021). Assessment of Imaging Performance and Accuracy for the Diagnostic Evaluation of Wilms Tumor in Kids in the ERA of Contrast Based CT Scan with Histopathological Correlation: A Study in Tertiary Care Hospital. International Journal of Innovative Research in Medical Science, 6(10), 668–673. https://doi.org/10.23958/ijirms/vol06-i10/1219

Copyrights & License

Copyright © 2021 Ashraf Amirali Jaideep Darira Hina Pathan Sorath Murtaza Munaza Irshad this is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.